منابع مشابه
Chronic myelogenous leukaemia (CML)
Evidence exists for the involvement of the most primitive and quiescent hematopoietic stem cell compartiment (CD34+/CD38-, Thy1+): t(9;22) is found in myeloid progenitor and in B-lymphocytes progenitors, but, involvement of the T-cell lineage is extremely rare. The existence of a highly quiescent stem cell population has been demonstrated in patients with CML. More recently, the presence of Ph ...
متن کاملChronic myelogenous leukaemia (CML)
Clinics Splenomegaly; chronic phase (lasts about 3 yrs) with maintained cell’s normal activities, followed by accelerated phase(s)(blasts still < 15%), and blast crisis (BC-CML) with blast cells > 30%; blood data: WBC: 100 X 10/l and more during chronic phase, with basophilia; a few blasts; thrombocytosis may be present; low leucocyte alkaline phosphatases; typical acute leukaemia (AL) blood da...
متن کاملChronic myelogenous leukaemia in infancy.
Chronic myelogenous leukaemia is an uncommon disease in infancy and is usually termed congenital in cases seen at or within a few days after birth. The latter do not appear to differ from those seen later except that they are believed to have started during intra-uterine life, and Kelsey and Andersen (1939) have laid down certain criteria for the diagnosis, which might be briefly stated as symp...
متن کاملAcute Transformation In Chronic Myelogenous Leukaemia
Fifty-three patients with chronic myeloid leukaemia (CML) were included in this study (25 females & 28 males) and followed-up from October 2003 till October 2005 included for the evidence of acute transformation. Twenty-one patients (39.6%) transformed to acute phase , 16 patients(76.1%) of them transformed during the first 4 years of diagnosis. Fifteen patients (71.4 %) ) transformed to acute ...
متن کاملRibosomal Synthesis of Macrocyclic Peptides for Chronic Myelogenous Leukaemia Treatment
Introduction In Nature, the vast majority of polypeptides are synthesized through translation of the messenger RNA (mRNA) by the joint action of the ribosome and the transfer RNA (tRNA). The mRNA is a transcribed copy of the gene that carries genetic information in the form of series of three-nucleotide sequences referred as ‘codon’. Each codon corresponds to a specific amino acid or a terminat...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2000
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2000.02216.x